Mathematical Modeling of in vitro Release Kinetics of Diclofenac Sodium from Complex Coacervates of Irvingia gabonensis and Acacia Gums with Gelatin

Author(s)

Uzondu, A. L. E.,, Abali, S. O., Onyia, A.

Author's Affiliation

Abstract

The study is aimed at comparatively evaluating the in vitro release kinetics of diclofenac sodium from complex coacervates of Irvingia gabonensis and acacia gums and gelatin gum using mathematical models. Pre-optimized coacervates and physical admixtures of irvingia / gelatin gums and acacia / gelatin gums were formed at different ratio strengths of 1:2 and 2:1 respectively. Some amounts of the coacervates and physical admixtures equivalent to 500 mg diclofenac sodium were filled into separate hard gelatin capsules. The release profiles of diclofenac sodium from these hard capsule devices were determined spectrophotometrically. The release profiles were compared for similarity by applying the FDA ƒ2 statistic. The in vitro release mechanisms and kinetics were determined by analysis with models like Korsmeyer-Peppas, zero order, first order, Higuchi and Hixon-Crowell Cube-root release models. Results showed that the physical admixtures had their maximum drug release within four hours while the complex coacervates had sustained drug release for more than six hours. The complex coacervates had similar release profiles but their mechanisms of drug release were different and kinetics of drug release followed different mathematical models.

Keywords

Mathematical Modeling, Complex Coacervates, Release Profiles, Kinetics and Mechanisms

Cite This Article

Uzondu, A. L. E., Abali, S. O., & Onyia, A. (2014). Mathematical Modeling of in vitro Release Kinetics of Diclofenac Sodium from Complex Coacervates of Irvingia gabonensis and Acacia Gums with Gelatin. International Journal for Pharmaceutical Research Scholars, 3(1), 481-488.