Microwave Assisted Multicomponent Synthesis of Promising Insulin Inhibitor and Mcl-1 Antagonist Thiazolidinone & Pyrazolo Thiazolidine Derivatives

Author(s)

Khot, S. S., Kapase, V. S., Kenawade, S., Dhongade, S. R.

Author's Affiliation

Abstract

This work involves synthesis of thiazolidinone derivatives by condensation of various amines with carbon disulfide and chloro acetic acid in presence of NaHCO₃ with microwave assisted  multicomponent reactions with  microwaves (140watts) in a scientific microwave oven, which on further condensation in another MCR with different aromatic aldehydes and hydrazides furnish the 1,3,6-Triaryl-hexahydro-pyrazolo[3,4-d]thiazole-5-thione derivatives [I (a-g)]. Library of such pyrazolo thiazolidine derivatives has been generated and the structures were subjected to PASS for finding their probabilities of being active biologically. QSAR study of the libraries was done to find out most active molecules.   3-Phenyl-2-thioxo-thiazolidin-4-one. (I A) is found most active compound as insulin inhibitor and Mcl-1 antagonist.

Keywords

Thiazolidinone, Insulin Inhibitor, Pyrazolo Thiazolidine

Cite This Article

Khot, S. S., Kapase, V. S., Kenawade, S., & Dhongade, S. R. (2014). Microwave Assisted Multicomponent Synthesis of Promising Insulin Inhibitor and Mcl-1 Antagonist Thiazolidinone & Pyrazolo Thiazolidine Derivatives. International Journal for Pharmaceutical Research Scholars, 3(1), 363-373.