Microwave Assisted Organic Synthesis of Novel 1, 2, 4-Triazolium Salts as Antimicrobial Agents

Author(s)

Rai, P.R., Somani, R.R., Darekar, M.P., Kandpile, P.S., Sharma, J.S.

Author's Affiliation

Abstract

Microwave assisted organic synthesis (MAOS) is emerging as a new tool in the organic synthesis. This approach is considered to be an important step towards green chemistry. This technique stands out as it is more eco-friendly compared to traditional heating methods in organic chemistry. Synthesis of new chemical entities is the most important step in drug discovery. The increasing problem of antimicrobial resistance has made it highly urgent to design and develop novel types of antimicrobial agents consisting different chemical structures of the traditional drugs. It is rational to investigate triazolium compounds as novel antimicrobial agents since triazole has shown a broad range of pharmacological activity. In view of this, a series of 1, 2, 4-triazolium disubstituted derivatives have been synthesized starting from Isoniazid. The structures were confirmed with the help of IR, NMR, and Mass spectroscopy. The compounds were tested for antibacterial, antifungal and anti-tubercular activity and have shown poor to moderate activity.

Keywords

Green chemistry, 1, 2, 4-triazolium salts, Anti-bacterial, Anti-fungal, Anti-tubercular

Cite This Article

Rai, P. R., Somani, R. R., Darekar, M. P., Kandpile, P. S., & Sharma, J. S. (2017). Microwave Assisted Organic Synthesis of Novel 1, 2, 4-Triazolium Salts as Antimicrobial Agents, International Journal for Pharmaceutical Research Scholars (IJPRS), 6(4), 37-45.