Nanoparticles: Nasal Delivery of Drugs

Author(s)

Sachan, A. K., Singh, S.

Author's Affiliation

Abstract

Diseases of the Central Nervous System (CNS) such as schizophrenia, meningitis, migraine, parkinson’s disease and alzheimer’s disease require delivery of the drug to the brain for treatment. Treatment of CNS diseases are difficult because of presence of blood – brain barrier (BBB). This review highlights about the nanoparticles which represent, one of the possibilities to overcome this barrier. NPs and other colloidal drug-delivery systems modify the kinetics, body distribution and drug release of an associated drug. Intranasal administration of drug offers an alternative to the oral and parenteral drug delivery. In recent years, Nasal delivery has been explored as an alternative administration route to target drugs directly to the brain via the olfactory neurons. Intranasal administration circumvents first-pass elimination and drug absorption is rapid due to the existence of a rich vasculature and a highly permeable structure within the nasal membranes which provide faster onset of action as compared to peroral administration. The purpose of this review, to provide complete information about nasal drug delivery system such as advantage, limitations, mechanism of drug absorption, absorption improvement aspects and novel drug formulations.

Keywords

Brain, Nanoparticles (NPs), Nasal delivery, Microemulsion

Cite This Article

Sachan, A. K., & Singh, S. (2014). Nanoparticles: Nasal Delivery of Drugs. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(3), 33-44.