Novel Synthesis, Characterization and Antimicrobial Evaluation 2-Azetidinone and 4-Thiazolidinone Derived from 4 Nitro Benzoic Acid Schiff Bases

Author(s)

Prasad, A. V. G. S., Rao, P. V., Prasad, P. S. S.

Author's Affiliation

Abstract

In the present study an intermolecular reductive Schiff base formation from nitro derivative and benzaldehydes is carried out in the presence of iron powder and dilute acid. Schiff base synthesis is usually acid-catalyzed and usually require refluxing the mixture of aldehydes (or ketone) and amine in polar organic medium. In the present study new Schiff base compounds derived from para nitro benzoic acid with 4 hydroxy benzaldehyde and 4 dimethylamino benzaldehyde. The synthesized Schiff base derivates 2-azetidinone and 4-thiazolidinone were characterized by IR, and 1H NMR spectroscopy. The Schiff base ligands have also been tested in vitro for their antibacterial and anti fungal activity. The experimental results suggest that Schiff base derivatives are more potent in anti bacterial and anti fungal activities.

Keywords

Schiff bases, 4 nitro benzoic acid, 4 hydroxy benzaldehyde and 4 dimethyl amino benzaldehyde, Antibacterial activity; Antifungal activity

Cite This Article

Prasad, A. V. G. S., Rao, P. V., & Prasad, P. S. S. (2014). Novel Synthesis, Characterization and Antimicrobial Evaluation 2-Azetidinone and 4-Thiazolidinone Derived from 4 Nitro Benzoic Acid Schiff Bases. International Journal for Pharmaceutical Research Scholars, 3(1), 57-62.