Phytochemical Analysis of Curcuma Amada by FTIR and UV-VIS Spectroscopic Analysis

Author(s)

Sahu, R., Saxena, J.

Author's Affiliation

Abstract

The study was designed to evaluate the effect of addition of fentanyl to intrathecal bupivacaine on hemodynamic stability in controlled hypertensive patients undergoing orthopedic surgery. Material and methods: sixty patients of either sex belonging to ASA Grade II and III undergoing elective orthopedic lower limb surgeries under spinal anesthesia were studied in this prospective, comparative, double blinded study. Patients were distributed randomly into two groups of 30 each. Group A received 3 ml (15mg) bupivacaine & group B received 2.5ml (12.5mg) bupivacaine with 25 µgm fentanyl. All patients were observed for onset and duration of sensory and motor block, duration of analgesia, changes of pulse rate, blood pressure, ST-T changes, ectopic beats and side effects. Results: onset of sensory and motor blockade was comparable in both the groups. Duration of sensory, motor block and analgesia were more in Group B than Group A. Patients were hemodynamically more stable in Group B than Group A. Hypotension and requirements of vasopressor less in Group B. Incidence of ST-T changes and ectopic beats were less in group B then Group A. Conclusion: it was concluded that use of intrathecal fentanyl 25µgm as adjuvants to bupivacaine 12.5mgm in controlled hypertensive patients can be a safer alternative with less side effects and provide good hemodynamic stability.

Keywords

Fentanyl, Bupivacaine, Spinal Anaestheia, Orthopedic Surgery, Hypertension

Cite This Article

Sahu, R., Saxena, J. (2015). Phytochemical Analysis of Curcuma Amada by FTIR and UV-VIS Spectroscopic Analysis, International Journal for Pharmaceutical Research Scholars (IJPRS), 4(2), 458-461.