Phytochemical Screening and Evaluation of Cardioprotective Activity of Ethanolic Extract of Trigonella foenum – graecum against Isoproterenol Induced Myocardial Infarction Rats

Author(s)

Deepika, E., Sivakumar, V., Selvapriya, B., Dinesh, K., Sadiq, A. M.

Author's Affiliation

Abstract

The objectives of the present study were phytochemical screening and evaluate the effects of ethanol extract of Trigonella foenum-graecum on cardiac functions and histopathological changes in isoproterenol-induced myocardial infarction (MI). The whole plant was extracted with ethanol by soxlet apparatus and subjected to analysis the phytochemical and evaluates the cardioprotactive activity through wistar rats. They were assigned to 5 groups of normal control, isoproterenol, pre-treatment with ethanol extract of Trigonella foenum-graecum 200 and 400 mg/kg of body weight the extract one in a day concurrent with myocardial infarction rats. And verapamil standard drug in the dose of 5µmol/kg body weight. All groups except normal groups received isoproterenol (85 mg/kg) for 2 consecutive days was used to induce myocardial infarction. Phytochemical screening indicated the presence of important principal active compound in ethanol extract of Trigonella foenum-graecum. The results of the study demonstrate that ethanol extract of Trigonella foenum-graecum strongly protected the myocardium against isoproterenol-induced infarction and proved that the cardio protective effects.

Keywords

Myocardial infarction, Trigonella foenum-graecum, Isoproterenol

Cite This Article

Deepika, E., Sivakumar, V., Selvapriya, B., Dinesh, K., & Sadiq, A. M. (2014). Phytochemical Screening and Evaluation of Cardioprotective Activity of Ethanolic Extract of Trigonella foenum - graecum against Isoproterenol Induced Myocardial Infarction Rats. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(3), 146-154.