Polymeric Nanoparticles: New Approaches towards Targeted Cancer Therapy with Biomedical Applications

Author(s)

Panwar, J., Dwivedi, N., Shukla, V. K., Easwari, T. S.

Author's Affiliation

Abstract

Nanotechnology is a dynamic field and new products containing nanoparticles are being marketed every week. Encapsulation of therapeutic drugs inside nanoparticles has become the new norm in the field of drug delivery. Nanoparticles increase the therapeutic efficacy of the drugs by providing high loading efficiencies, shielding when in circulation, ability to target tumors, enhanced accumulations, and triggered release inside tumors. Polymeric nanoparticles have seen an unprecedented growth and usage in drug delivery and diagnostics in recent decades, and have emerged as extremely promising candidates for targeted delivery owing to their tunable properties, and the flexibility to design systems which respond to external stimuli such as pH, hyperthermia, redox, ultrasound, and magnetic field. This review summarizes recent exciting developments in the field of targeted polymeric nanoparticles for delivery of anti-cancer drugs, with a particular focus on functionalization with ligands, stimuli responsive, focusing on the synthesis and biomedical applications of polymer based nanoparticles. . Delivery of genes into neurons can be achieved by optimization the size of nanoparticles, as well as the conformation of their surface. Further a critical overview of their design principles, drug release performance, and therapeutic advantages over conventional nanoparticles is discussed.

Keywords

Polymer nanoparticle, Liposome, Drug accumulation, Drug delivery system, Drug release, Nanoencapsulation, Particle size, Surface property

Cite This Article

Panwar, J., Dwivedi, N., Shukla, V. K., & Easwari, T. S. (2014). Polymeric Nanoparticles: New Approaches towards Targeted Cancer Therapy with Biomedical Applications. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(2), 551-562.