Preparation and Evaluation of Chlorpheniramine Maleate Microcapsules by Ionic-gelation Method

Author(s)

Pandey, S., Kumar, S.

Author's Affiliation

Abstract

The study was conducted for preparation of microcapsules of CPM. (chlorpheniramine maleate) By ionic gelation method by different combinations of hydrophilic polymers. Microcapsules were characterized for particle  size and shape by scanning electron microscopy, angle of repose, drug content CPM : Chlorpheniramine maleate is a first generation  alkylamine antihistamine used in the prevention of the symptoms of allergic conditions such rhinitis and urticaria through the literature survey it was found that no significant work was done on preparation of microcapsules  of CPM  through ionic gelatin technique. Microcapsules were characterized by particle size analysis, SEM studies, IR spectrophotometry and in vitro release studies. SEM and IR studies indicated that microcapsules were spherical, free flowing and there was no significant interaction between drug and polymer. The percentage yield was found to be in the range of 60 %to 72% indicated good yield of microcapsules.

Keywords

Microcapsules, Chlorpheniramine Maleate, Ionic Gelation Method, In-Vitro Release

Cite This Article

Pandey, S., & Kumar, S. (2014). Preparation and Evaluation of Chlorpheniramine Maleate Microcapsules by Ionic-gelation Method. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(2), 491-495.