Protective Effect of Naringin on Testosterone Induced Benign Prostatic Hyperplasia in Rats

Author(s)

Naresh, K. N., Aparna, B., Veeresh, B

Author's Affiliation

Abstract

Major components of plants being flavonoids containing polyphenolic derivatives which posses antioxidant property have shown to improve uncontrolled growth of the prostate gland and urinary tract symptoms, which are associated with benign prostatic hyperplasia. Our study investigated whether Naringin prevents testosterone induced prostatic hyperplasia in rats by virtue of its antioxidant property. In vitro studies were carried out to assess the protective effect of prostate tumor cell lines. BPH was induced in experimental groups by intramuscular injection of Testosterone Enanthate on day 1, 7 and 14. Naringin was administered daily by oral gavage for a period of 21 days. On 22^nd day, rats were sacrificed, prostate tissue weighed and histopathological studies were carried out. Prostate zinc, oxidative parameters were measured. Treatment with Naringin showed significant inhibition of prostate enlargement and restored the histoarchitecture when compared with positive control group. In conclusion, the present study showed that Naringin reduced the elevated levels of both prostate weight and prostate weight to body weight ratio, markers of testosterone induced prostatic hyperplasia in rats.

Keywords

Benign prostatic hyperplasia, Testosterone, Antioxidant, Naringin

Cite This Article

Naresh, K. N., Aparna, B., & Veeresh, B. (2013). Protective Effect of Naringin on Testosterone Induced Benign Prostatic Hyperplasia in Rats. International Journal for Pharmaceutical Research Scholars (IJPRS), 2(2), 239-244.