Rapid and Economic Synthesis of Schiff Bases of Para Chloro Nitro Benzene

Author(s)

Prasad, A. V. G. S., Rao, P. V.

Author's Affiliation

Abstract

Schiff base synthesis is usually acid-catalyzed and usually require refluxing the mixture of aldehydes (or ketone) and amine in organic medium. In the present study an intermolecular reductive Schiff base formation from nitroarenes and benzaldehydes to yield diarylimines is carried out in the presence of iron powder and dilute acid. The method was also compared with conventional method for determination of production efficiency and production economic. In the present study new Schiff base compounds derived from para chloro nitro benzene with iso vaniline and pyridine 2 carboxaldehyde. Both the Schiff bases were characterized by IR, and 1H NMR spectroscopy. The Schiff base ligands have also been tested in vitro for their antibacterial and anti fungal activity. The experimental results suggest that Schiff base ligands are more potent in anti bacterial and anti fungal activities.

Keywords

Schiff bases, 4 chloro nitro benzene, Isovaniline, Pyridine 2 carboxaldehyde, Antibacterial activity; Antifungal activity

Cite This Article

Prasad, A. V. G. S., & Rao, P. V. (2013). Rapid and Economic Synthesis of Schiff Bases of Para Chloro Nitro Benzene. International Journal for Pharmaceutical Research Scholars (IJPRS), 2(4), 401-404.