Review on Orodispersible Tablets

Author(s)

Pagar, R., Ahirrao, S., Yallatikar, T., Wagh, M.

Author's Affiliation

Abstract

Tablet is the most popular dosage forms existing today because of its convenience of self-administration, compactness and easy manufacturing; however the problem of swallowing is common fact which leads to poor patient compliance. To overcome this drawback, fast dissolving tablets (FDT) has emerged as alternative oral dosage forms. These are novel types of tablets that disintegrate in saliva within few seconds without chewing and additional water. According to European Pharmacopoeia, the FDT should disperse/disintegrate in less than three minutes. The basic approach used in development of FDT is the use of superdisintegrant like Cross linked carboxymelhylcellulose (Croscarmeliose), Primogel, Polyvinylpyrrolidone (Polyplasdone) etc. which provide instantaneous disintegration of tablet after putting on tongue. The bioavailability of some drugs may be increased due to absorption of drugs in oral cavity and also due to pregastric absorption of saliva containing dispersed drugs that pass down into the stomach. Moreover, the amount of drug that is subject to first pass metabolism is reduced as compared to standard tablets.

Keywords

Orodispersible tablets, Fast dissolving tablets, Superdisintegrants, ODT

Cite This Article

Pagar, R., Ahirrao, S., Yallatikar, T., Wagh, M. (2015). Review on Orodispersible Tablets, International Journal for Pharmaceutical Research Scholars (IJPRS), 4(1), 302-312.