Self Micro Emulsifying Drug Delivery System (SMEDDS) – A Promising Future Aspect to Enhance the Oral Bioavailability of Poorly Water Soluble Drugs

Author(s)

Talath, F., Syed, M.S. , Husna, B. , Asad, A.K. , Basha, S.A.

Author's Affiliation

Abstract

Oral route is most preferred one as there is ease of administration and it is a painless approach. This favored route is restricted to those drug molecules that are absorbent over the gastric mucosa. Solubilization in gastrointestinal tract is the rate limiting step for absorption of these drugs. Various approaches in the formulation such as micronization, solid disbandment, and complexation with cyclodextrins have been emerging rapidly. Self Micro Emulsifying Drug Delivery Systems (SMEDDS) are the isotropic mixtures of natural or synthetic oils, solid or liquid surfactants or instead, single or alternative hydrophilic solvents and co solvents that are having distinctive potential of forming fine oil in water micro emulsions on mild turbulence subsequently followed by dilution in the aqueous media, like in the fluids of GI tract. Self Micro Emulsifying Drug Delivery System (SMEDDS) favorably provide the dissolved drug form and also its small size of droplets imparts substantial interfacial area for the absorption of drugs. It can simply get penetrated into the gastrointestinal tract which is the major advantage over other emulsions. The major hindrance for the progress of SMEDDS is the insufficiency of better base in-vitro models for the evaluation of the formulations. Various excipients used are Tween 80, Cremophor RH 40, Polyethylene glycol 400, Labrafac Lipophile WL 1349 etc. The main aim of this is to augment the oral bioavailability of poorly water soluble drugs which may be a promising approach in future.

Keywords

Cyclodextrins, Oral bioavailability, Self Micro Emulsifying Drug Delivery Systems (SMEDDS), Polyethylene glycol 400

Cite This Article

Talath, F., Syed, M.S. , Husna, B., Asad, A.K., Basha, S.A. (2016). Self Micro Emulsifying Drug Delivery System (SMEDDS) - A Promising Future Aspect to Enhance the Oral Bioavailability of Poorly Water Soluble Drugs, International Journal for Pharmaceutical Research Scholars (IJPRS), 5(1), 219-226.