Spectrophotometric determination of pka of schiff base ligand

Author(s)

Lawankar, T.R., Mahajan, D.T.

Author's Affiliation

Abstract

Schiff bases are a significant group of organic compounds that have biological activities and miscellaneous applications because of their antibacterial, antivirus activities, metal complexation and other Pharmacological activities. The simple and meticulous method used for the determination of the stability constants of the complexes by means of UV-visible spectrophotometry depending on the theoretical interpretation of the stoichiometry, Jobs and Yoe-Jones, methods was proposed. In present work, proton ligand stability constant (pKa) of substituted  hydroxy Schiff base ligand  2,2’-((ethane-1,2-diylbis(azanylylidene))bis(ethan-1-yl-1-ylidene))bis(4-methylphenol) (H₂L)  have been  investigated by spectrophotometric method.  Determination of pKa values has studied at different concentrations of ligand solution. pKa values are calculated at pH 4.82,5.12,5.40,5.70 & 5.90 by using standard literature method. The ruggedness of the determined result was also validated in this study for producing exact pKa value. The results obtained from this work were compared with those obtained using the potentiometric method. The difference between the results found with these two methods was approximately 0.04 units.

Keywords

Schiff base, Spectrophotometric method, pKa determination

Cite This Article

Lawankar, T.R., Mahajan, D.T. (2017). Spectrophotometric determination of pka of schiff base ligand. , 6(1), 171-175.