Stability Indicating HPLC Method for Estimation of Palonosetron Hydrochloride in Tablet Dosage Form

Author(s)

Patel, H.P., Ladva, B.J., Patel, H.K., Nayak, B.S.

Author's Affiliation

Abstract

To develop precise, accurate and reproducible stability indicating HPLC method for determination of Palonosetron hydrochloride in its tablet dosage form. Stability indicating HPLC method was developed using BDS Hypersil C8 column (250 x 4.6mm, 5µm) with ACN: Water (70:30) as mobile phase with flow rate was 1.0ml/min, injection volume was 20µl and detection wavelength 242nm. Retention time of Palonosetron hydrochloride was found to be 4.387 min. Palonosetron hydrochloride was found to degrade significantly under Acidic, Alkaline, Neutral and Oxidative conditions and comparatively stable under photolytic condition. The proposed stability indicating HPLC method can be successfully employed in estimation of tablet dosage form in regular QC and stability analysis.

Keywords

Palonosetron Hydrochloride, Stability Studies, HPLC, Forced Degradation

Cite This Article

Patel, H.P., Ladva, B.J., Patel, H.K., Nayak, B.S. (2015). Stability Indicating HPLC Method for Estimation of Palonosetron Hydrochloride in Tablet Dosage Form, International Journal for Pharmaceutical Research Scholars (IJPRS), 4(2), 258-263.