Study and Impact Evaluation of Particle Size Distribution on Physicochemical Properties of Three Different Tablet Formulations through Sieve Technology

Author(s)

Amin, M. R., Biswas, S., Rahman, M. R., Bhuiyan, J. R., Rana, M. S.

Author's Affiliation

Abstract

The objective of this study was to evaluate the impact of Particle size distribution by means of sieving of granules for tablet compression through mesh screen and the relationship between this size distribution and physical & chemical properties of tablets (e.g., hardness, thickness, target weight, appearance, friability, disintegration time, dissolution and potency). Optimization of particle size distribution was also carried out for taking the effects of hardness, thickness, target weight, appearance, friability, disintegration time, dissolution and potency into consideration. The physical properties of granules for tablet compression and tablets were found to be significantly affected by this factor. That was mean, the different particle size distribution with different size of mesh screen found to be governed the physical and chemical properties of tablets.  So, it can be said that the evaluation parameters such as hardness, thickness, target weight, appearance, friability, disintegration time, dissolution and potency was found to be affected by the particle size distribution. Potency was not affected significantly due to different particle size distribution. Dissolution rate increased with decreasing granule size (over the range 16-20 mesh to 60-80 mesh) and probability of rising sticking problem &poor  flow property was observed with decreasing granule size  but not strictly proportionally to the corresponding increase in the apparent surface area of the granules. Increasing starch content of granules (varied from 0 to 20 per cent) resulted in an increase in dissolution rate. Increasing precompression pressure (varied from 715 to 5720 Kg/cm²) caused an increase in dissolution rate. This was probably due to fracturing of the harder granules into smaller particles with greater specific surface area or bonding of the softer granules (prepared at lower slugging pressure) during their compression into tablets.

Keywords

INN, Mesh, Particle Size Distribution, Surface Area and Physico-Chemical Property

Cite This Article

Amin, M. R., Biswas, S., Rahman, M. R., Bhuiyan, J. R., Rana, M. S. (2014). Study and Impact Evaluation of Particle Size Distribution on Physicochemical Properties of Three Different Tablet Formulations through Sieve Technology. International Journal for Pharmaceutical Research Scholars, 3(1), 448-463.