Synthesis and Biological Evaluation of Novel Schiff Bases and their Derivatives

Author(s)

Prasad, A. V. G. S., Rao, P. V., Prasad, P. S. S.

Author's Affiliation

Abstract

In the present study an intermolecular reductive Schiff base formation from nitro derivative and benzaldehydes is carried out in the presence of iron powder and dilute acid. Schiff base synthesis is usually acid-catalyzed and usually require refluxing the mixture of aldehydes (or ketone) and amine in polar organic medium. In the present study new Schiff base compounds derived from ortho nitro benzoic acid with 2- hydroxy benzaldehyde, 4- hydroxy benzaldehyde and 2 furfuraldehyde. The synthesized Schiff base derivatives (2-azetidinones) were characterized by IR, and 1H NMR spectroscopy. The Schiff base ligands and derivatives have also been tested in vitro for their antibacterial and anti fungal activity. The experimental results suggest that Schiff base derivatives are more potent in anti bacterial and antifungal activities.

Keywords

Schiff bases, 4 nitro benzoic acid, 4 hydroxy benzaldehyde, 4 dimethyl amino benzaldehyde, Antibacterial activity, Antifungal activity

Cite This Article

Prasad, A. V. G. S., Rao, P. V., & Prasad, P. S. S. (2014). Synthesis and Biological Evaluation of Novel Schiff Bases and their Derivatives. International Journal for Pharmaceutical Research Scholars, 3(1), 69-73.