Synthesis and Characterization of Some Pharmaceutically important N’-Benzylidene-2-(3-(3-Isopropoxy-5-(Trifluoromethyl)Phenyl)-1H-1,2,4-Triazol-1-yl)-Acetohydrazides

Author(s)

Panera, C.L., Joshi, H.S.

Author's Affiliation

Abstract

A series of fifteen novel analogues of 1H-1,2,4-triazole derivatives were synthesized. The targeted 1H-1,2,4-triazoles were prepared by reacting 1H-1,2,4-triazolylacetohydrazide with various substituted benzaldehydes  in the presence of acid catalyst. Various reaction conditons were tried to optimize the product yields. The structures of all the synthesized compounds have been characterized by using elemental analysis, FT-IR, 1H NMR, 13C NMR spectroscopy. Purity of all the compounds has been checked on thin layer chromatographic plate and NMR analysis technique.

Keywords

Acetohydrazide, Schiff-base, 1H-1,2,4-triazole

Cite This Article

Panera, C.L., Joshi, H.S. (2016). Synthesis and Characterization of Some Pharmaceutically important N’-Benzylidene-2-(3-(3-Isopropoxy-5-(Trifluoromethyl)Phenyl)-1H-1,2,4-Triazol-1-yl)-Acetohydrazides, International Journal for Pharmaceutical Research Scholars (IJPRS), 5(4), 61-72.