Synthesis and In Vitro Antibacterial Activity of Nitrogen and Sulphur Containing Thiadiazole Derivatives

Author(s)

Bhor, R.J., Kunkulol, R.R.

Author's Affiliation

Abstract

Thiadiazole and Triazoles heterocyclic compounds were reported with wide range of biological activities. Hence it was planned to synthesize and screen for their antibacterial and antifungal (in vitro) activity. Azoles like Thiadiazole and Triazoles have been reported to play an important role as antibacterial, antifungal and anti-inflammatory activity. 2-(2-benzyl-4-chlorophenoxy) acetohydrazide derivatives were synthesized and screened for antibacterial activity and antifungal activity. Some thiadiazole like 2-[(2-benzyl-4-chlorophenoxy) methyl]-5-(4-Nitrophenyl)-1, 3, 4-thiadiazole (BA) and 2-[(2-benzyl-4-chlorophenoxy) methyl]-5-(4-Flurophenyl)-1, 3, 4-thiadiazole (BB) etc. were synthesized by a sequence of reactions starting from Con.H₂SO₄ and 2-[(2-benzyl-4-chlorophenoxy) acetyl]-N-(4-Nitrophenyl) hydrazine carbothioamide (AA) and 2-[(2-benzyl-4-chlorophenoxy) acetyl]-N-(4-flurophenyl) hydrazine carbothioamide(AB). The antibacterial and antifungal activities of carbothioamide derivatives, was tested by disc diffusion method (Mueller Hinton Agar (M173) medium).  All the compounds tested against bacteria showed comparable or less antibacterial activities than the reference drug. Differences in their activity depend on the substitution of different groups. More specifically, best antibacterial activity & antifungal activity among synthetic analogues was shown by compound AA, AB, AC, BA, BB, and BC, possess very good activity against Staphylococcus aureus, Gram negative Escherichia coli, and Pseudomonas aeruginosa with Gentamycin at 100 μg/ml were used as standard drugs for antibacterial activities.

Keywords

Cite This Article

Bhor, R.J., Kunkulol, R.R. (2016). Synthesis and In Vitro Antibacterial Activity of Nitrogen and Sulphur Containing Thiadiazole Derivatives, International Journal for Pharmaceutical Research Scholars (IJPRS), 5(2), 55-63.