Synthesis, Characterization and Antimicrobial Activity of some 2, 6-di(coumarin-3-yl)-4-[1-aryl-3-(bezofuran-2-yl)-1H-pyrazol-4-yl]pyridines

Author(s)

Patel, K.N., Brahmbhatt, D.I.

Author's Affiliation

Abstract

The synthesis of various 2,6-di(coumarin-3-yl)-4-[1-aryl-3-(bezofuran-2-yl)-1H-pyrazol-4-yl]pyridines (5a-r) has been carried out. The target compounds have been synthesized by reacting 3-{3-[1-aryl-3-(benzofuran-2-yl)-1H-pyrazol-4-yl]acryloyl}coumarins (coumarin chalcones) (3a-f) with 3-coumarinoyl methyl pyridinium bromide salts (4a-c) in the presence of ammonium acetate in glacial acetic acid under Krohnke's reaction condition. All the synthesized compounds were characterized by IR, ¹H-NMR, ¹³C-APT and representative mass spectral analysis. All the compounds were screened for their antimicrobial activity.

Keywords

Dicoumarinyl Pyridines, Benzofuran, Krohnke Reaction, Antimicrobial Activity

Cite This Article

Patel, K. N., & Brahmbhatt, D. I. (2017). Synthesis, Characterization and Antimicrobial Activity of some 2, 6-di(coumarin-3-yl)-4-[1-aryl-3-(bezofuran-2-yl)-1H-pyrazol-4-yl]pyridines, International Journal for Pharmaceutical Research Scholars (IJPRS), 6(1), 90-103.