Synthesis, Characterization and Biological Evaluation of Novel Morpholine Derivatives

Author(s)

Hedapara, K. R., Kharadi, G. J.

Author's Affiliation

Abstract

Considering the biological and chemical relevance of Morpholine derivatives, we have devised novel derivatives of morpholine. The series of morpholine derivatives were synthesized in high yield and quality by reaction of 4-(4-aminophenyl)morpholin-3-one with various aromatic o-hydroxy aldehyde giving schiff base, which on reduction and further reaction with chloroacetyl chloride gives chloro derivatives. The obtained chloro derivative is cyclized using strong base to give novel morpholine derivatives. The synthesized compounds were confirmed by NMR (1H, ¹³C), IR, Mass spectroscopy, elemental analysis.  All the compounds were screened vitro antibacterial activities. The Compound 6a exhibited good inhibition towards antimicrobial activity compared to the other compounds.

Keywords

4-(4-Aminophenyl) Morpholin-3-one, Morpholine Derivatives, Aromatic o-Hydroxy Aldehyde Derivatives, Chloroacetyl Chloride, Base

Cite This Article

Hedapara, K. R., & Kharadi, G. J. (2014). Synthesis, Characterization and Biological Evaluation of Novel Morpholine Derivatives. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(3), 132-137.