Synthesis, Characterization and Biological Evaluation of Some Thiazole Derivatives Bearing 2,2,Difluorobenzo[d][1,3]Dioxole Nucleus

Author(s)

Patel, P. K., Godhaviya, P. K.

Author's Affiliation

Abstract

A series of thiazole derivatives have been synthesized and tested for in vitro antibacterial and antifungal activity on different microorganisms. Synthesis of 2,2-difluoro-N’-(4-substitutedphenylthiazol-2-yl)[d][1,3]dioxole-5-carbohydrazide have been carried out from 2-[(2,2-difluoro-1,3-benzodioxol-5-yl)carbonyl]hydrazine carbothioamide and substituted phenacyl bromide in dioxane. The structure and purity of the original compounds were confirmed by IR, LCMS, NMR and elemental analysis.

Keywords

2-[(2,2-difluoro-1,3-benzodioxol-5-yl)carbonyl]hydrazine carbothioamide, Phenacyl bromide, substituted thiosemicarbazide

Cite This Article

Patel, P. K., & Godhaviya, P. K. (2014), Synthesis, Characterization and Biological Evaluation of Some Thiazole Derivatives Bearing 2,2,Difluorobenzo[d][1,3]Dioxole Nucleus. International Journal for Pharmaceutical Research Scholars, 3(1), 31-34.