Synthesis, Characterization and Biological Screening of novel N-[2-chloro-4-(trifluromethyl) phenyl]-4-(substituted phenyl)-3, 6-Dimethyl-2-oxo-1, 2, 3, 4-tetrahydropyrimidine-5-carboxamide

Author(s)

Chauhan, N.,, Nimavat, K., Vyas, K. B.

Author's Affiliation

Abstract

N-[2-chloro-4-(trifluromethyl)phenyl]-4-(substitutedphenyl)-3,6-Dimethyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide (4a-o) are synthesized. The synthesis of (4a-o) was achieved by acid catalysed cyclocondensation of N-(2-chloro-4-(trifluromethyl) phenyl)-3-oxobutanamide, N-methyl urea and benzaldehydes. The products were characterized by FT-IR, mass spectra, ¹H NMR and elemental analyses. The newly synthesized compounds were subjected to various biological activities viz., antimicrobial.

Keywords

Pyrimidine, N-(2-chloro-4-(trifluromethyl) phenyl)-3-oxobutanamide, N-methyl urea, Multi component cyclocondensation

Cite This Article

Chauhan, N., Nimavat, K., Vyas, K. B. (2012). Synthesis, Characterization and Biological Screening of novel N-[2-chloro-4-(trifluromethyl) phenyl]-4-(substituted phenyl)-3, 6-Dimethyl-2-oxo-1, 2, 3, 4-tetrahydropyrimidine-5-carboxamide, International Journal for Pharmaceutical Research Scholars (IJPRS), 1(3), 22-27.