Synthesis, Characterization and Biological Study of Novel Pyrrole Derivatives

Author(s)

Mishra, R. R., Vyas, K. B., Nimavat, K. S.

Author's Affiliation

Abstract

A facile condensation of aromatic aldehydes with 2-(5-(phenoxymethyl)-2-thioxo-1,3,4-oxadiazol-3(2H)-yl)aceto hydrazide (1)  was give the corresponding N’-aryl-2-(5-(phenoxymethyl)-2-thioxo-1,3,4-oxadiazol-3(2H)-yl)acetohydrazide (2a-e) in good yield. Cyclo condensation of compounds (2a-e) with maleic anhydride yields 2-aryl-5-oxo-1-(2-(5-(phenoxymethyl)-2-thioxo-1,3,4-oxadiazol-3(2H)-yl)acetamido)-2,5-dihydro-1H-pyrrole-3-carboxylic acid (3a-e). The structures of these compounds were established on the basis of analytical and spectral data. All the newly synthesized compounds were evaluated for their antibacterial and antifungal activities.

Keywords

2-(5-(phenoxymethyl)-2-thioxo-1,3,4-oxadiazol-3(2H)-yl)acetohydrazide, pyrrole, antibacterial and antifungal activities

Cite This Article

Mishra, R. R., Vyas, K. B., Nimavat, K. S. (2012). Synthesis, Characterization and Biological Study of Novel Pyrrole Derivatives, International Journal for Pharmaceutical Research Scholars (IJPRS), 1(3), 33-39.