Synthesis of 1,2,3,5- Thiatriazines, their Antimicrobial Screening and their Isomerization into 1,2,3,5-Tetrazines

Author(s)

Deshmukh, P. N., Gaidhane, M. K., Berad, B. N.

Author's Affiliation

Abstract

Series of new heterocyclic compounds 2H-4-(pyrid-4yl)-5-arylidene / alkylidene-amino-6-phenylimino-5,6-dihydro-1,2,3,5-thiatriazine (8a-f) have been synthesized by the basification of 2H-4-(pyrid-4yl)-5-arylidene / alkylidene – amino – 6- phenylimina-5,6-dihydro-1,2,3,5-thiatriazine hydrochloride (7a-f).  The later were synthesized by the interaction of 1-aryl / alkylidene-3-(pyrid-4y) – dihydro formazan (5a-f) with N-phenyl-S-chloroisothiocarbamoyl chloride.  The synthesized compounds were further isomerised into 1 phenyl –4-(pyrid-4yl)-5-aryldene / alkyldene amino –6-thio-1,2,3,5-tetrazines (9a-f) by using 5 % ethanolic sodium hydroxide. Compound (8) on benzalyation with excess 10 % sodium hydroxide and benzoyl chloride afforted corresponding benzoyl derivatives (10 a-f). The structures of newly synthesized compounds were confirmed on the basis of their elemental IR ¹H-NMR and mass spectral analysis. The title compounds were assayed for both antifungal and antibacterial activity against gram positive and gram negative micro-organisms.

Keywords

Synthesis, 1,2,3,5-thiatriazines, antibacterial and antifungal activity, isomerization into 1,2,3, 5- tetrazines

Cite This Article

Deshmukh. P. N., Gaidhane, M. K., Berad, B. N. (2013). Synthesis of 1,2,3,5- Thiatriazines, their Antimicrobial Screening and their Isomerisation into 1,2,3,5-Tetrazines. International Journal for Pharmaceutical Research Scholars (IJPRS), 2(4), 244-253.