Synthesis of Certain Fluoro Containing Pyrimidine Derivatives

Author(s)

Patel, K.N., Joshi, K.A., Ram, H.K.

Author's Affiliation

Abstract

Synthesis of a series of 4-(4-(2,6-difluoro-4-nitrophenoxy)phenyl)-N-(substitutedphenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxopyrimidine-5-carboxamide. (4a-j) was achieved from different N-(4-substitutedphenyl)-3-oxobutanamide, 4-(2,6-difluoro-4-nitrophenoxy) benzaldehyde and urea using few drops of conc. hydrochloric acid added and refluxed with ethanol so to the fine yield. The structures of the products were supported by FTIR, ¹H NMR and mass spectral data.

Keywords

4-(2,6-Difluoro-4-Nitrophenoxy) Benzaldehyde; Hydrochloric Acid, Urea Only Refluxed

Cite This Article

Patel, K.N., Joshi, K.A., Ram, H.K. (2015). Synthesis of Certain Fluoro Containing Pyrimidine Derivatives, International Journal for Pharmaceutical Research Scholars (IJPRS), 4(1), 210-214.