Synthesis of Ethyl (2-Aryl-3-oxo-2, 3, 4, 5-tetrahydrobenzo [f][1,4]Oxazepin-7-yl) thiazole-5-carboxylate

Author(s)

Patoliya, M. J., Kharadi, G. J.

Author's Affiliation

Abstract

Oxazepines, which were synthesized by different methods shown in literature also Oxazepines are great importance in heterocyclic chemistry and more importance in biology and pharmacology. Oxazepines are very biological active molecules. In this work we can synthesize Ethyl 2-(Aryl-3-oxo-2, 3, 4, 5-tetrahydrobenzo[f][1,4]oxazepin-7-yl)thiazole-5-carboxylate by using a different Schiff bases, which were synthesized from ethyl 2-(3-formyl-4-hydroxyphenyl)—methylthiazole-5-carboxylate and Benzyl Amines. During performing reaction get a 60-70% yield. The identification of product by 1H NMR, 13C NMR, IR, elemental analysis.

Keywords

Schiff Bases, Reduction, Chloroacetyl Chloride, Ring Closure, Benzoxazepines

Cite This Article

Patoliya, M. J., & Kharadi, G. J. (2014). Synthesis of Ethyl (2-Aryl-3-oxo-2, 3, 4, 5-tetrahydrobenzo [f][1,4]Oxazepin-7-yl) thiazole-5-carboxylate. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(2), 791-797.