Synthesis of M(II) Complexes with Clioquinol and their Evaluation of Antimicrobial, Antioxidant and Anti-tubercular Activity

Author(s)

Chaudhari, V. R., Nimavat, K. S., Vyas, K. B.

Author's Affiliation

Abstract

Co(II), Ni(II), Cu(II) and Mn(II) complexes synthesized by reflux of 6-bromo-3-(3-(4-chlorophenyl)acryloyl)-2H-chromen-2-one, Ciprofloxacin and various transition metal. ¹H, ¹³C, IR and ESI Mass confirm the formation of ligand. The metal complexes were characterized on the basis of various spectroscopic techniques like IR studies and elemental analysis while the geometry of complexes was octahedral which is confirmed by electronic spectra and thermogravimetric analysis. The compounds were subjected to antimicrobial, antioxidant and anti-tubercular activity screening using serial broth dilution method and Minimum Inhibitory Concentration (MIC) is determined. Mn(II) complex has shown significant antifungal activity with an MIC of 6.25µg/mL while Cu(II) complex is noticeable for antibacterial activity at the same concentration. Anti-TB activity of the ligand has enhanced on complexation with Ni(II) and Co(II) ions. While Ni(II) complex shows superior antioxidant activity than other complexes.

Keywords

Transition Metal Complex, Ciprofloxacin, Biological Activity

Cite This Article

Chaudhari, V. R., Nimavat, K. S., & Vyas, K. B. (2015). Synthesis of M(II) Complexes with Clioquinol and their Evaluation of Antimicrobial, Antioxidant and Anti-tubercular Activity, International Journal for Pharmaceutical Research Scholars (IJPRS), 4(4), 202-213.