Synthesis of N-1 Fused Heterocyclic Derivatives Using Potassium Carbonate and PEG-400 as Green Catalyst

Author(s)

Wanegaonkar, A.M., Bhitre, M.J., Bairagi, S.H.

Author's Affiliation

Abstract

Indole, benzimidazole and its substituted derivatives continue to capture the attention due to its synthetic utility and broad range of pharmacological activities. The N-1-substituted fused heterocyclic compounds are usually biologically active and may be applied as potential therapeutic alternatives to antitumor drugs. The molality of catalyst affects the yield of reaction. The catalyst like anhydrous K₂CO₃ for its N-1 alkylation or arylation of indole-3-carboxaldehyde and 2-acetylbenzimidazole in the presence and absence of phase transfer catalyst such as PEG-400 and TEBAC was observed. The molar ratio 1:4 of anhydrous K₂CO₃ with PEG-400 gives, mild reaction conditions with excellent yields. The ease of synthetic method provides an attractive route to the synthesis of N-1-substituted fused heterocyclic derivatives which may act as biological alternatives.

Keywords

2-acetyl –Benzimidazole, Indole-3-Carboxaldehyde, Green Synthesis, PTC

Cite This Article

Wanegaonkar, A.M., Bhitre, M.J., Bairagi, S.H. (2016). Synthesis of N-1 Fused Heterocyclic Derivatives Using Potassium Carbonate and PEG-400 as Green Catalyst, International Journal for Pharmaceutical Research Scholars (IJPRS), 5(1), 140-145.