Synthesis of Plausible Fluoro Containing Pyrimidine Derivatives

Author(s)

Kothari, P., Desai, H.

Author's Affiliation

Abstract

Synthesis of a series of 4-(4-(4-(trifluoromethyl)-2-nitrophenoxy)phenyl)-N-(substitutedphenyl) -1,2,3,4-tetrahydro-6-methyl-2-oxopyrimidine-5-carboxamide (4a-j) was completed from 4-(4-(trifluoromethyl)-2-nitrophenoxy)benzaldehyde, N-(substituted phenyl)-3-oxobutanamides  and using catalytical amount of Conc. hydrochloric acid in methanol the product obtained was isolated. So to the excellent yield. The structures of the products were supported by FTIR, ¹H NMR and mass spectral data.

Keywords

N-(Substituted phenyl)-3-Oxobutanamides, 4-(4-(Trifluoromethyl)-2-Nitrophenoxy) Benzaldehyde, Conc. HCl, Methanol Only Refluxed

Cite This Article

Kothari, P., & Desai, H. (2016). Synthesis of Plausible Fluoro Containing Pyrimidine Derivatives, International Journal for Pharmaceutical Research Scholars (IJPRS), 5(1), 192-195.