Synthesis of Urea based Chalcone Derivatives and Evaluate its Biological Activity

Author(s)

Desai, A., Vyas, K.B., Patel, R.N., Nimavat, K.S.

Author's Affiliation

Abstract

Chalcones have been the center of attraction for researchers from several decades due to nits innumerous therapeutic application, Efforts have been done in my research to synthesized chalcones and their derivatives that further reacts with various substituted aldehyde to give corresponding substituted chalcone derivatives. Now these derivatives on condensation with Guanidine nitrate gives the vast range of phenyl pyrimidine amine Derivatives. Structure elucidation of synthesized compound had been made on the basis of element analysis, 1H NMR Spectra studies. The microbial activity of the synthesized compounds has been studied against the species bacillus subtillis, staphylococcus aureus, Escherichia coli, and salmonella typhi.

Keywords

Synthesis, Heterocyclic substituted chalcone derivatives, Pyrimidine derivatives, Chalcones

Cite This Article

Desai, A., Vyas, K.B., Patel, R.N., Nimavat, K.S. (2016). Synthesis of Urea based Chalcone Derivatives and Evaluate its Biological Activity, International Journal for Pharmaceutical Research Scholars (IJPRS), 5(2), 1-6.