The Arterial Wall Lysosomal Stabilizing and Hypolipidemic Effect of Mono and Poly unsaturated Fatty Acids

Author(s)

Al-Khafaji, A. T., Majid, W. J., Thwaini

Author's Affiliation

Abstract

Both mono- and polyunsaturated fat lowered LDL-Cholesterol levels when they replaced saturated fat. On the other hand, many studies indicated that polyunsaturated fat lowered HDL-Cholesterol, whereas monounsaturates did not. This study was designed to address the controversy regarding a differential effect of monounsaturates versus polyunsaturates on serum lipids and on lysosomal stability of experimentally induced hyperlipidemia in rats, as parameters critically affected the incidence of ischemic heart diseases. The statistical analysis showed that oleic acid was more effective in reducing serum levels of triglycerides, total cholesterol, LDL- cholesterol and VLDL- cholesterol. In addition, oleic acid also significantly more effective in elevation of HDL-cholesterol and stabilizing of aortic wall lysosomes, in hyperlipidemic rats in comparison with normal saline treated group.

Keywords

Monounsaturated, Polyunsaturated, Fatty Acid, Hyperlipidemia, Lipid Profile, Lysosomes

Cite This Article

Al-Khafaji, A. T., Majid, W. J., & Thwaini, M. M. (2014). The Arterial Wall Lysosomal Stabilizing and Hypolipidemic Effect of Mono and Poly unsaturated Fatty Acids. International Journal for Pharmaceutical Research Scholars (IJPRS), 3(4), 276-280.