Today about 70% of drugs are taken orally and are found not to be as effective as desired. To improve such characters transdermal drug delivery system has emerged. Transdermal drug delivery system (TDDS) provides a means to sustain drug release as well as reduce the intensity of action and thus reduce the side effects associated with its oral therapy and differs from traditional topical drug delivery. Transdermal Drug Delivery System is the system in which the delivery of the active ingredients of the drug occurs by means of skin. Several important advantages of transdermal drug delivery are a limitation of hepatic first-pass metabolism, enhancement of therapeutic efficiency and maintenance of steady plasma level of the drug. Various types of transdermal patches are used to incorporate the active ingredients into the circulatory system via the skin. This review article covers a brief outline of the principles of transdermal permeation, various components of a transdermal patch, approaches of a transdermal patch, evaluation of a transdermal system, its application with its limitation.
Keywords
Transdermal delivery, Patch, Microneedle, Method of preparation, Evaluation parameter
Cite This Article
Patel, D.S., Patel, M.V., Patel, K.N., Patel, B.A., Patel, P.A. (2012). Transdermal Patches: A Complete Review on Transdermal Drug Delivery System, International Journal for Pharmaceutical Research Scholars, 1(1), 62-78.
INTRODUCTION
Transdermal drugs are self-contained, discrete dosage form. Transdermal drug delivery system is the system in which the delivery of the active ingredients of the drug occurs by the mean of skin. Skin is an effective medium from which absorption of the drug takes place and enters the circulatory system. Delivering medicine to the general circulation the skin is seen as a desirable alternative to taking it by mouth or by the oral route. By passing through the gastrointestinal tract would obviate the GI irritation that frequently occurs and avoids first pass inactivation by the liver. Further, steady absorption of the drug over hours or days is usually preferable to the blood level spikes and troughs produced by oral dosage forms.
