Virus like Particles as Vaccines

Author(s)

Dwarkaprasad, A. A., Rao, S.

Author's Affiliation

Abstract

Virus Like Particles are formed by the structural elements of viruses representing a specific class of subunit vaccine that mimic the structure of authentic virus particle. They are recognized readily by the immune system and presents viral antigens in a more authentic conformation. Virus Like Particles have therefore shown dramatic effectiveness as a candidate vaccine. To date, a wide variety of VLP-based candidate vaccines targeting various viral, bacterial, parasitic and fungal pathogens, as well as non-infectious diseases, have been produced in different expression systems. Some VLPs have entered clinical development and a few have been licensed and commercialized. The aim of the present review is to give an account of achievements brought about by the availability of Virus Like Particles to serve as Vaccines. The main objective of the topic is to review the basic idea about the production of virus like particles used as vaccine against various diseases. Here we study various methods and processes involved in the production of virus like particles. Production of VLP-based vaccine for Human Pappilomavirus, Influenza and Hepatitis B using different expression systems is been reviewed in these manuscript.

Keywords

Virus like particle, VLP, HPV VLP, HEP B VLP, Influenza Virus VLP

Cite This Article

Dwarkaprasad, A. A., & Rao, S. (2013). Virus like Particles as Vaccines. International Journal for Pharmaceutical Research Scholars (IJPRS), 2(4), 512-544.